A combined Covid-19 and flu vaccine may soon be a reality, though not in time for the current flu season. Moderna recently announced positive results from the late-stage trial of its new Covid-flu combination vaccine, mRNA-1083. This development could revolutionize vaccination strategies, especially for older adults.
Breakthrough Trial Results
Moderna’s Chief Medical Affairs Officer, Francesca Ceddia, highlighted the “breakthrough results” of the trial. Participants who received mRNA-1083 demonstrated an enhanced immune response compared to those who received separate Covid and flu vaccines. This improved response was consistent even among participants aged 65 and older, a group typically less responsive to vaccines.
Trial Design and Outcomes
The Phase 3 trial was a randomized, observer-blind, active control study, involving approximately 8,000 adults divided into two age groups: 50-64 and 65 and older. The study compared the immune response of these groups receiving the combination vaccine mRNA-1083 to those receiving separate vaccines—Moderna’s Spikevax (Covid-19 vaccine) and either Fluzone HD or Fluarix (flu vaccines).
Safety and Side Effects
The combined vaccine was well-tolerated, with adverse reactions similar to those experienced with the separate vaccines. Common side effects included pain at the injection site, tiredness, muscle pain, and headaches.
Future Steps and Public Health Impact
While the study results are not yet peer-reviewed, Moderna plans to present the data at an upcoming medical conference and submit it for publication. The company also intends to discuss next steps with the FDA, aiming for approval by fall 2025.
Conclusion
Moderna’s Covid-flu combination vaccine, mRNA-1083, represents a promising advancement in vaccine technology, offering enhanced immune response and convenience. With ongoing discussions and potential regulatory approval by 2025, this vaccine could become a vital tool in protecting public health against both Covid-19 and the flu.
Reference: https://investors.modernatx.com/news (Moderna News)
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