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Groundbreaking Study Proposes Guiding Principles to Tackle Algorithm Bias and Promote Health Equity

Panel of Experts Offers Framework to Address Racial and Ethnic Disparities in Health Care Algorithms

Date: December 17, 2023

In a significant stride toward combating algorithmic bias and fostering health equity, a diverse panel of experts assembled by the Agency for Healthcare Research and Quality (AHRQ) and the National Institute for Minority Health and Health Disparities (NIMHD) has put forth guiding principles. These principles aim to mitigate and prevent bias in health care algorithms, particularly in relation to racial and ethnic disparities.

Study Overview:

The comprehensive study, titled “Guiding Principles to Address the Impact of Algorithm Bias on Racial and Ethnic Disparities in Health and Health Care,” sheds light on the crucial role algorithms play in healthcare, from diagnosis and treatment to resource allocation. The study emphasizes that biased algorithms can lead to adverse outcomes, especially for minoritized groups and historically marginalized populations.

Key Findings:

The panel’s findings resulted in the development of a conceptual framework and five guiding principles applicable across the life cycle of health care algorithms. The principles are strategically designed to promote health and health care equity, ensuring transparency, authentic community engagement, and accountability for fairness.

Five Guiding Principles:

  1. Promote Health and Health Care Equity: The study advocates for the integration of health equity goals throughout the algorithm’s life cycle, emphasizing the importance of problem formulation, data selection, algorithm development, deployment, and monitoring.
  2. Ensure Transparency and Explainability: Stakeholders, including developers, institutions, users, and regulators, are urged to make algorithms transparent, explainable, and interpretable to diverse audiences, fostering informed decision-making.
  3. Authentically Engage Patients and Communities: The study stresses the ethical imperative of involving patients and communities in all phases of the algorithm life cycle, earning trustworthiness through transparency, ethical practices, and timely disclosures.
  4. Identify Algorithmic Fairness Issues and Trade-offs: Recognizing that fairness issues arise from ethical choices and technical decisions, the study advocates for explicit identification, transparency, and explainability of health care algorithmic fairness issues and trade-offs.
  5. Establish Accountability for Equity and Fairness: Model developers and users are called upon to accept responsibility for achieving equity and fairness in algorithm outcomes, with organizations urged to establish processes and accountability metrics throughout the algorithm life cycle.

Conclusion:

The study concludes by highlighting the need for collaborative efforts among stakeholders to create systems, regulations, and policies that effectively mitigate and prevent algorithm bias in health care. It underscores the importance of dedicated resources, public support, and a commitment to avoiding the mistakes of the past in algorithm usage.

This groundbreaking study represents a pivotal step toward ensuring that health care algorithms prioritize equity, transparency, and fairness, ultimately benefiting patients and communities alike.

Credit: JAMA Network Open, Marshall H. Chin

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Lunar Anthropocene: Scientists Declare a New Epoch as Humans Transform the Moon

Researchers have declared a new epoch for the moon, known as the lunar Anthropocene, signifying the significant alterations that humans have made and plan to make to the lunar surface. In a comment article published in Nature Geoscience, scientists argue that the moon’s landscape is changing due to human activities, marking the start of a distinct era.

The lunar Anthropocene is suggested to have commenced in 1959 when Russia’s Luna 2 spacecraft became the first to land on the moon. The researchers emphasize the importance of officially recognizing the changes made by humanity to dispel the notion that the lunar surface is static and unaffected.

Lead author Justin Holcomb, a geological researcher at the University of Kansas, draws parallels with the discussion of the Anthropocene on Earth, highlighting the significant impact humans have had on the planet. The goal is to avoid delaying the recognition of the Lunar Anthropocene until observable lunar halos caused by human activities become apparent.

Human activities on the moon have left traces, including the iconic golf balls and flags from the first lunar landing, as well as less glamorous items like human excrement and litter. As humanity looks towards the moon with plans to dig into its surface and potentially establish a presence, the researchers stress that cultural processes are surpassing natural geological processes on the moon.

Holcomb points out that rovers, landers, and human movement are disturbing the lunar regolith (surface material), leading to substantial changes. With multiple countries gearing up for lunar exploration, the researchers aim to initiate discussions about humanity’s impact on the moon’s surface before irreversible changes occur.

As the new space race unfolds, the lunar landscape is expected to undergo significant transformations in the coming decades, raising challenges and highlighting the need to acknowledge and address the human impact on Earth’s celestial neighbor.

Credit: Nature Geoscience

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US Strengthens Export Controls on AI Chips in Escalating Tech Conflict with China

The Biden administration is intensifying the technological standoff with China by imposing stricter export controls on specific semiconductors, notably advanced artificial intelligence chips. The US Commerce Department has introduced new regulations that limit the export of these chips to China and extend these restrictions to 21 other nations under arms embargoes, such as Iran and Russia. These measures are designed to obstruct China’s acquisition of advanced computing chips for military and weaponry applications, excluding chips used in phones, video games, and electric vehicles. This move has resulted in a decline in the stock prices of prominent American chip manufacturers, including Nvidia, Intel, and AMD. China has voiced criticism of the new rules, while the US has emphasized its commitment to national security and its efforts to impede China’s military progress. The ongoing tech rivalry between the US and China has also encompassed constraints on sales of chipmaking equipment and exports of vital semiconductor materials. The US Semiconductor Industry Association has called for enhanced collaboration with allies to safeguard the US semiconductor sector. European firms like ASML are currently assessing the ramifications of these rules, which may impact their business with China. Additionally, the US Department of Commerce has included 13 Chinese entities on a list of firms prohibited from doing business with US companies due to national security concerns, citing their involvement in the development of advanced computing chips.

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Scientists Unravel Solar System’s Puzzling Spin: A Force Beyond Physics at Play

Breakthrough Research Reveals the Mysterious Mechanism Governing Inner Solar System’s Rotation

In a significant scientific breakthrough, researchers believe they have finally cracked the enigma of why the inner solar system defies the laws of physics by spinning at a much slower rate than theory suggests. This baffling phenomenon, which has puzzled astronomers for decades, has now been unveiled as a complex interplay between charged particles and magnetic forces.

At the heart of this mystery lies the inner ring of the solar system, a region teeming with thin layers of gas and dust known as accretion disks. These disks gracefully spiral around young stars, gradually moving inward over time. According to the laws of angular momentum, this spiraling motion should cause the inner part of the disk to spin faster, much like a figure skater twirling faster when drawing their arms in.

However, observations have consistently revealed that the inner portion of these accretion disks, although spinning faster than the outer part, does not rotate as swiftly as anticipated. Researchers had proposed several explanations, including friction between the inner and outer components of the disk or the presence of magnetic fields generating a “magnetorotational instability.” Yet, these theories fell short of providing a satisfactory answer.

Enter Paul Bellan, a professor of applied physics at Caltech, who embarked on a quest to unveil the underlying mechanism driving this intriguing phenomenon. Bellan’s research took a novel approach by analyzing the trajectories of individual atoms, electrons, and ions within the gas making up the accretion disk.

Using a complex simulation involving approximately 40,000 neutral particles and about 1,000 charged particles subject to gravity and magnetism, Bellan discovered a crucial detail. The simulation revealed that collisions between neutral atoms and charged particles led to positively charged ions spiraling inward while negatively charged electrons spiraled outward. This behavior disrupted the conservation of angular momentum but introduced a new force called “canonical angular momentum.”

Canonical angular momentum encompasses the original angular momentum along with an added quantity reliant on the charge of a particle and the surrounding magnetic field. For neutral particles, these forces are indistinguishable, but charged particles are profoundly impacted by the magnetic field.

The disparity in charge causes both positive and negative particles to accumulate canonical angular momentum, resulting in neutral particles losing angular momentum and shifting inward. Although seemingly small in scale, this minute distinction has a profound impact on the solar system’s rotation. Remarkably, only one in a billion particles needs to be charged to account for the observed loss of angular momentum in neutral particles.

This discovery transforms the accretion disk into a colossal battery, with a positive terminal near the center and a negative terminal at the edge. This generates a substantial electric flow, energizing astrophysical jets that extend in both directions, a phenomenon long observed by astronomers without knowledge of its origin.

The groundbreaking research, titled “Neutral-charged-particle Collisions as the Mechanism for Accretion Disk Angular Momentum Transport,” has been published in the prestigious Astrophysical Journal. This newfound understanding of the inner solar system’s peculiar rotation sheds light on the intricate interplay between charged particles, magnetic forces, and the forces governing our celestial neighborhood.

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Researchers Successfully Extract RNA from Extinct Species, Marking a Historic Breakthrough

Geneticists have achieved a groundbreaking scientific feat by isolating and decoding RNA molecules from an extinct Tasmanian tiger specimen, which was over 130 years old and stored at the Swedish Museum of Natural History. This achievement provides valuable insights into how the genes of this long-extinct species functioned and was detailed in a study published in the journal Genome Research.

Lead study author Emilio Mármol Sánchez, a computational biologist at the Centre for Palaeogenetics and SciLifeLab in Sweden, highlighted the significance of RNA in understanding the animal’s biology, explaining that it offers a unique window into the cells and tissues of the thylacine right before its extinction.

The Tasmanian tiger, roughly the size of a coyote, was a marsupial predator that disappeared nearly 2,000 years ago in most regions except Tasmania, where it was hunted to extinction by European settlers. The last thylacine, named Benjamin, lived in captivity and died from exposure in 1936.

While the primary goal of this research wasn’t de-extinction, it could contribute to ongoing efforts to bring back the Tasmanian tiger in some form. Andrew Pask, who leads a project aimed at resurrecting the thylacine, hailed the research as “groundbreaking” and noted that it expands our understanding of extinct species’ biology.

RNA, often considered a temporary copy of DNA, was previously thought to break down quickly and was not expected to endure. However, this study demonstrates that RNA can be retrieved from long-extinct animals, challenging previous assumptions. The research team hopes to extend their work to recover RNA from even older extinct species, such as the woolly mammoth.

By sequencing RNA from the Tasmanian tiger specimen’s skin and skeletal muscle tissues, scientists identified thylacine-specific genes, contributing to the animal’s transcriptome. This RNA-based approach complements DNA analysis, offering a more comprehensive understanding of an animal’s biology. Mármol Sánchez likened DNA to a recipe book for life, while RNA allows each “restaurant” (or cell) to create different dishes based on that reference book.

In essence, this groundbreaking research not only provides new insights into extinct species’ genetics but also opens the door to further discoveries and a deeper understanding of the biology of long-lost creatures.

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Discover What’s New in iPhone Features with the iOS 17 Release

Calling all iPhone users: the day has arrived for you to dive into a world of exciting new features as Apple releases iOS 17. This latest operating system is set to redefine the iPhone experience, promising to make it more personal and intuitive than ever before.

Back in June, Apple offered a tantalizing glimpse of iOS 17 at the Worldwide Developer Conference, sharing the spotlight with its groundbreaking Vision Pro mixed-reality headset. However, amid the whirlwind of innovation, some of the remarkable details about iOS 17 may have slipped by unnoticed.

Starting today, iPhone users can update to iOS 17 with a simple trip to the Software Update section in their phone’s Settings app. While many are eager to embrace the latest technological advancements, some prefer to exercise caution by backing up their critical data before embracing the new software. If you’re concerned about potential bugs, you might also choose to wait for the second version of iOS 17, expected to roll out in the coming weeks.

Now, let’s delve into some of the standout features that iOS 17 has in store for you.

Live Voicemail and Enhanced FaceTime

One of the most talked-about additions is the Live Voicemail feature. This game-changing feature transcribes incoming voicemail messages in real-time, granting users the ability to decide whether to answer the call while the caller is still leaving their message. When the “Silence Unknown Callers” setting is activated, unknown numbers are automatically directed to Live Voicemail.

Furthermore, FaceTime receives a significant facelift with the introduction of video messages for when someone misses a video call. iOS 17 also introduces a range of expressive reactions, including hearts, balloons, fireworks, and more, all of which can be triggered through simple gestures during FaceTime calls.

“Hey Siri” Becomes Simply “Siri”

Prepare to adapt your vocal commands as saying “Siri” will now suffice to activate Apple’s voice assistant, eliminating the need for the “Hey Siri” prefix. This change aims to make interactions with Siri feel more natural. Additionally, Siri will become more adept at handling consecutive requests once activated, streamlining your interactions.

NameDrop Feature for Contact Sharing

iOS 17 introduces the NameDrop feature, simplifying the process of sharing contact information with new acquaintances. iPhone users can bring their devices close to each other, similar to AirDrop, to exchange names and Contact Posters. The Contact Poster update allows users to design a custom image that appears during calls, creating a consistent caller ID photo.

Personalization is key, with the ability to customize your contact card “poster” with a photo or memoji of your choice.

Revamped Autocorrect

Autocorrect gets a major upgrade with the integration of a transformer language model, enhancing word prediction and providing sentence-level autocorrections that address a wider range of grammatical errors. Predictive text recommendations now appear in-line as you type, simplifying the process of adding entire words or completing sentences.

The iOS keyboard becomes more intuitive over time, learning your typing habits, and adapting to words you commonly misspell, even those you intentionally want to type.

New Standby Mode, Journal App, and More

iOS 17 also introduces StandBy, a full-screen experience that offers glanceable information when your iPhone is on its side and charging. Customize the display with a clock, favorite photos, or frequently used widgets, perfect for your nightstand or desk.

In the pipeline, Apple’s Journal app aims to promote reflection and gratitude through daily journaling, enhancing your overall well-being.

In conclusion, iOS 17 brings a host of exciting features and improvements to the iPhone ecosystem. Whether it’s the real-time transcription of Live Voicemail, the revamped Siri experience, or the intuitive NameDrop feature, iOS 17 is designed to elevate your iPhone experience to new heights. So, get ready to update your device and explore the future of mobile technology.

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The Potential of AI as a Game-Changing Tool in Addressing Male Infertility

A team of researchers led by Dr. Steven Vasilescu from the University of Technology Sydney has developed an AI software called SpermSearch to assist in solving male infertility. The AI can rapidly identify viable sperm in samples taken from severely infertile men, doing so 1,000 times faster than a highly trained human observer. This technology is particularly beneficial for men with a condition called non-obstructive azoospermia (NOA), where they have no sperm in their ejaculate. Traditionally, embryologists manually search for healthy sperm in surgically removed testes tissue, a time-consuming and labor-intensive process.

SpermSearch significantly speeds up this process by analyzing photographs of tissue samples and instantly identifying viable sperm. The AI was trained using thousands of images of complex tissue samples to achieve this remarkable speed. While SpermSearch is not intended to replace embryologists, it acts as an assistive tool, saving critical time in identifying viable sperm for fertilization.

The ability to quickly find viable sperm is crucial in fertility treatments, as there is a limited time window for fertilization once eggs are collected. Male infertility has become a growing concern, with factors such as pollution, smoking, poor diets, lack of exercise, and stress contributing to a decline in sperm counts.

Other researchers are also exploring AI applications in addressing male infertility. For instance, another technique tracks the speed and movement of sperm tails to assess their health, while a different approach identifies DNA damage in individual sperm cells.

While these AI developments are promising, they are still in the proof-of-concept stage and will require further clinical trials before becoming commercially available. Nonetheless, such advancements offer hope for men facing infertility issues, potentially increasing their chances of fathering biological children. The University of Technology Sydney team is currently preparing for clinical trials, with the ultimate goal of achieving a live pregnancy using their AI technology.

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iPhone 15 Abandons Lightning Charger Following EU Directive

Apple has confirmed that the upcoming iPhone 15 will no longer have its proprietary lightning charging port, instead opting for a USB-C cable as the new standard, following a directive from the European Union. Alongside this announcement, a new Apple Watch series with advanced features was unveiled. Some experts expressed concerns that these updates may not be sufficiently groundbreaking. Apple also introduced a USB-C-to-lightning port adapter for users with existing accessories. This move is aimed at making charging standards more uniform, reducing e-waste, and saving consumers money. However, critics argue it may lead to discarded cables. In response, Apple pledged environmental initiatives, such as carbon neutrality and increased use of recycled materials. The iPhone 15 offers brighter screens and improved cameras, with the Pro models featuring a titanium frame and customizable “action button.” The new Apple Watch incorporates gesture control. Some experts questioned whether consumers would be willing to pay high prices for devices that may not represent major advancements. The iPhone 15 starts at $998, and the Pro model at $1249 in the US. Despite recent challenges, Apple’s smartphone shipments experienced a relatively small decline compared to other major manufacturers in the global smartphone market.

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Understanding Tactical Nuclear Weapons: Their Role and Implications in Ukraine

The recent escalation of tensions in Ukraine has brought tactical nuclear weapons into the international spotlight. These weapons, designed for battlefield use rather than strategic defense, have become a topic of concern as Russian President Vladimir Putin has issued threats involving their potential use. To shed light on the significance of these weapons and their relevance in the current geopolitical landscape, we turn to an international security expert.

Tactical Nuclear Weapons: An Overview

Tactical nuclear weapons, also known as battlefield or nonstrategic nuclear weapons, were originally developed to counter overwhelming conventional forces on the battlefield. They differ from their strategic counterparts in terms of size, explosive yield, and delivery range. While experts may debate precise definitions, tactical nuclear weapons typically have lower explosive yields, ranging from fractions of a kiloton to about 50 kilotons, as compared to strategic nuclear weapons, which can yield over a megaton.

Their delivery systems are characterized by shorter ranges, typically under 310 miles (500 kilometers), making them suitable for use in localized conflicts. Unlike strategic weapons designed for long-range attacks, tactical nuclear weapons are intended for shorter-range targets on the battlefield.

The possession and deployment of tactical nuclear weapons vary among nations. For instance, the U.S. has reduced its reliance on these weapons, with most of its remaining stockpile deployed in Europe. In contrast, Russia has retained a substantial arsenal of tactical nuclear weapons, estimated at around 2,000, and has incorporated them more prominently into its nuclear strategy.

The Destructive Power of Tactical Nuclear Weapons

One critical aspect that sets tactical nuclear weapons apart is their significantly higher destructive power compared to conventional weaponry. Even at the same explosive energy, nuclear explosions are exponentially more powerful than chemical explosions, leading to widespread destruction. Furthermore, the aftermath of a nuclear explosion includes deadly radiation fallout, similar to the Chernobyl nuclear disaster in 1986, which contaminates air, soil, water, and food supplies.

The Question of Tactical Nuclear Weapons’ “Useability”

The fundamental question surrounding tactical nuclear weapons is whether they are more “useable” in practice and whether their use could potentially trigger a full-scale nuclear war. Historically, these weapons were developed as a means to overcome the perception that large-scale nuclear attacks were unthinkable, leading to concerns that strategic nuclear weapons were losing their value as a deterrent.

However, any use of tactical nuclear weapons would invoke defensive nuclear strategies. The idea of “tactical” nuclear weapons is contested, with many experts arguing that any nuclear weapon use fundamentally alters the strategic landscape. As former U.S. Secretary of Defense James Mattis stated in 2018, “Any nuclear weapon use any time is a strategic game changer.”

Tactical Nuclear Weapons in the Current Ukraine Crisis

Russian President Putin’s threats to use tactical nuclear weapons in Ukraine have raised concerns and discussions on their credibility and potential consequences. It is essential to recognize that the use of these weapons in Ukraine would likely not achieve any military objectives but would instead contaminate the claimed territory and risk spilling into Russia. Such a move could escalate the situation and invite direct NATO intervention.

Putin’s approach of preemptively annexing regions in eastern Ukraine, followed by threats of nuclear weapon use to defend them, has been met with skepticism. Many experts argue that this approach stretches Russia’s nuclear strategy beyond belief, as using tactical nuclear weapons in such a scenario is widely seen as strategically incredible.

In conclusion, the debate surrounding tactical nuclear weapons continues to be a complex and contentious issue in international security. While they were designed for battlefield use, their actual employment remains a subject of significant debate, especially in the context of contemporary conflicts like the one in Ukraine. The world watches closely as geopolitical tensions evolve, and the role of tactical nuclear weapons in modern warfare continues to be a topic of critical importance.

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The Dominance of Drones on Ukraine’s Battlefield: A Look at Modern Warfare

The use of drones has become a significant aspect of the ongoing war between Russia and Ukraine, complementing conventional weaponry. Drones are increasingly being utilized on the battlefield due to their improved speed, durability, and capabilities. They can travel for long distances, remain airborne for extended periods, and even reach high altitudes. Various types of drones are in use, including the Turkish Bayraktar TB2, American Switchblade 300 and 600, and Iranian Shahed 136. These drones serve multiple purposes, such as identifying enemy positions, designating targets for bombing, and adapting to changing situations after failed attacks.

Drones are seen as a crucial element in modern warfare, representing a revolution in military technology and tactics. They have become more accessible due to advancements in stabilised optics systems, night vision capabilities, and reduced costs. Both Russia and Ukraine have incorporated drones into their strategies, with Ukraine initially facing a shortage but subsequently developing its own drone capabilities. Russia, facing technological challenges due to sanctions, has turned to Iranian and Israeli models.

Despite the increasing use of drones, their current destructive capacity might not be sufficient to cause significant strategic damage. Drones are compared to aviation in World War I, evolving from a novelty to a potent weapon. Ukraine is actively seeking drone donations through its United24 website, aiming to enhance reconnaissance capabilities along its extensive front line. The exact number of drones in use remains disputed, with estimations varying between sources. Russia is also making significant drone acquisitions, including a recent contract for 2,000 units.

Various countries are involved in supplying drones to Ukraine and Russia, indirectly affecting the conflict. Drones with artificial intelligence are emerging, moving toward more autonomous control with less human intervention. Advances in drone technology have geopolitical implications, as tech companies like SpaceX become players in global conflicts. The integration of drones and their evolving capabilities continue to shape the course of the war between Russia and Ukraine.