August 27, 2024 – A new study published in the journal Frontiers in Cellular and Infection Microbiology reveals that men with high-risk human papillomavirus (HPV) infections may experience slightly higher levels of dead sperm cells, raising questions about the impact of the virus on male fertility.
Researchers from the Universidad Nacional de Córdoba in Argentina examined semen samples from 205 men, finding that those with high-risk HPV strains, particularly HPV 16, had 2.5 times more dead sperm cells than those with low-risk strains. While the study did not show a reduction in standard semen quality markers such as sperm concentration or motility, the increased sperm death may be linked to oxidative stress and DNA damage.
The study’s senior author, Dr. Virginia Rivero, emphasized the need for broader research to determine the full impact of high-risk HPV on male fertility. “Our findings suggest that high-risk HPV types could have a more detrimental effect on sperm health, potentially creating a local immunosuppressive environment,” Rivero said.
Despite these findings, experts caution against overreacting. Dr. Bobby Najari, a urologist at NYU Langone Health, noted that the overall number of dying sperm was relatively low and unlikely to significantly impact fertility in most cases. He stressed that the most critical indicators of male reproductive potential—sperm count and motility—remained similar between men with high-risk HPV and those without.
The study underscores the importance of HPV vaccination, particularly for boys, as a preventive measure against high-risk HPV infections. The CDC recommends that boys and girls receive the HPV vaccine around ages 11 to 12. However, vaccination rates among U.S. teens have stagnated since the COVID-19 pandemic, highlighting the need for renewed public health efforts.
While the clinical implications of the study remain unclear, it adds to the growing body of research on HPV’s potential impact on male fertility. Further studies with larger sample sizes are needed to clarify the connection between high-risk HPV infections and fertility outcomes in men.